The last decade has witnessed an explosion in the depth, variety, and amount of human
genetic data that can be generated. This revolution in technical and analytical capacities has …

Platelets are enucleated cell fragments derived from megakaryocytes that play key roles in
hemostasis and in the pathogenesis of atherothrombosis and cancer. Platelet traits are …

Platelets play an important role in hemostasis and other aspects of vascular biology. We
conducted a meta-analysis of platelet count GWAS using data on 536,974 Europeans and …

Genetic and environmental factors contribute to a substantial variation in platelet function
seen among normal persons. Candidate gene association studies represent a valiant effort …

Mean platelet volume (MPV) is increased in myocardial and cerebral infarction and is an
independent and strong predictor for postevent morbidity and mortality. We conducted a …

Platelet production, maintenance, and clearance are tightly controlled processes indicative
of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for …

Several genetic variants associated with platelet count and mean platelet volume (MPV)
were recently reported in people of European ancestry. In this meta-analysis of 7 genome …

Genetic investigations have led to important advances in our knowledge of genes, proteins,
and microRNA that influence circulating platelet counts, platelet size, and function. The …

Mean platelet volume (MPV), a measure of platelet size, is a potential biological marker of
platelet function. To date, a comprehensive analysis including known genetic and …

Background Genome-wide association studies are currently identifying new loci with
potential roles in thrombosis and hemostasis: these loci include novel polymorphisms …