Fatal COVID-19 pulmonary disease involves ferroptosis

B Qiu, F Zandkarimi, A Saqi, C Castagna, H Tan… - Nature …, 2024 - nature.com
SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood
mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron …

SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?

M Yang, CL Lai - Cell death discovery, 2020 - nature.com
Since the outbreak of the new coronavirus in 2019 (SARS-CoV-2), many studies have been
performed to better understand the basic mechanisms and clinical features of the disease …

Ferroptosis and multi-organ complications in COVID-19: mechanisms and potential therapies

Q Li, Z Chen, X Zhou, G Li, C Zhang, Y Yang - Frontiers in Genetics, 2023 - frontiersin.org
COVID-19 is an infectious disease caused by SARS-CoV-2, with respiratory symptoms as
primary manifestations. It can progress to severe illness, leading to respiratory failure and …

Ferroptosis and pyroptosis signatures in critical COVID-19 patients

C Peleman, S Van Coillie, S Ligthart, SM Choi… - Cell Death & …, 2023 - nature.com
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from
severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and …

[HTML][HTML] The potential role of ferroptosis in COVID-19-related cardiovascular injury

L Yang, Y Wu, W Jin, N Mo, G Ye, Z Su, L Tang… - Biomedicine & …, 2023 - Elsevier
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
emerged as a global health threat in 2019. An important feature of the disease is that …

[HTML][HTML] The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators

HM Habib, S Ibrahim, A Zaim, WH Ibrahim - Biomedicine & …, 2021 - Elsevier
Iron overload is increasingly implicated as a contributor to the pathogenesis of COVID-19.
Indeed, several of the manifestations of COVID-19, such as inflammation, hypercoagulation …

Is ferroptosis a key component of the process leading to multiorgan damage in COVID-19?

AM Fratta Pasini, C Stranieri, D Girelli, F Busti… - Antioxidants, 2021 - mdpi.com
Even though COVID-19 is mostly well-known for affecting respiratory pathology, it can also
result in several extrapulmonary manifestations, leading to multiorgan damage. A recent …

Ferroptosis in COVID-19-related liver injury: A potential mechanism and therapeutic target

Y Chen, Y Xu, K Zhang, L Shen… - Frontiers in Cellular and …, 2022 - frontiersin.org
The outbreak and worldwide spread of coronavirus disease 2019 (COVID-19), which is
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a …

Cardiac iron overload promotes cardiac injury in patients with severe COVID-19

MJ Baier, S Wagner, J Hupf, K Evert, M Evert… - Infection, 2022 - Springer
During the current SARS-CoV-2-pandemic, involvement of multiple organs in addition to the
respiratory tract has been observed. Cardiac manifestations, such as acute heart failure …

The link between ferroptosis and airway inflammatory diseases: A novel target for treatment

Z Lin, X Yang, L Guan, L Qin, J Ding… - Frontiers in Molecular …, 2022 - frontiersin.org
Ferroptosis is an iron-dependent mode of cell death characterized by intracellular lipid
peroxide accumulation and a redox reaction imbalance. Compared with other modes of cell …