Schistosomiasis is a serious public health problem, prevalent in tropical and subtropical
areas, especially in poor communities without access to safe drinking water and adequate …

Background DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate
dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against …

The emergence of drug-resistant malaria parasites continues to hamper efforts to control this
lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target …

Membrane-associated dihydroorotate dehydrogenase (DHODH) is an antimalarial
therapeutic target without an effective inhibitor. Studies on human DHODH (HsDHODH) led …

Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH), a key enzyme in the de
novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on …

Malaria is a parasitic disease that, in its most severe form, can even lead to death. Insect-
resistant vectors, insufficiently effective vaccines, and drugs that cannot stop parasitic …

Therapeutic agents brequinar sodium and leflunomide (Arava™) work by binding in a
hydrophobic tunnel formed by a highly variable N-terminus of family 2 dihydroorotate …

The flavoenzyme dihydroorotate dehydrogenase (DHODH) catalyzes the fourth reaction of
the de novo pyrimidine biosynthetic pathway, which exerts vital functions in the cells …

Plasmodium falciparum dihydroorotate dehydrogenase (pf DHODH) is a flavin-dependent
mitochondrial enzyme that provides the only route to pyrimidine biosynthesis in the parasite …

Background: Plasmodium falciparum dihydroorotate dehydrogenase (PfDODH) is one of the
enzymes currently explored in the treatment of malaria. Although there is currently no …