X Liu, Y Lu, S Qin - Future oncology, 2021 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a common cancer globally and a leading cause of cancer-related deaths. Although early-stage disease may be curable by resection, liver …
S Stein, MJ Pishvaian, MS Lee, KH Lee, S Hernandez… - 2018 - ascopubs.org
4074 Background: Advanced HCC is a lethal cancer with a high unmet medical need. Single- agent immunotherapy with PD-L1/PD-1 blockade or treatment (Tx) with anti-angiogenic …
MS Lee, BY Ryoo, CH Hsu, K Numata, S Stein… - The Lancet …, 2020 - thelancet.com
Background Dual blockade of PD-L1 and VEGF has enhanced anticancer immunity through multiple mechanisms and augmented antitumour activity in multiple malignancies. We …
MJ Pishvaian, MS Lee, BY Ryoo, S Stein… - Annals of …, 2018 - annalsofoncology.org
Background: Agents targeting angiogenesis or PD-L1/PD-1 signalling represent 2 types of approved treatments (tx) for HCC. In addition to its anti-angiogenic activity, bevacizumab …
A Rizzo, AD Ricci, G Brandi - Immunotherapy, 2021 - Taylor & Francis
Advanced hepatocellular carcinoma (HCC) patients present poor prognosis. However, recent years have seen the advent of several novel treatments in this setting, where the role …
A successful phase III trial for the combination of atezolizumab and bevacizumab (the IMbrave150 trial) in advanced hepatocellular carcinoma has recently been reported. This is …
RS Finn, S Qin, M Ikeda, PR Galle… - … England Journal of …, 2020 - Mass Medical Soc
Background The combination of atezolizumab and bevacizumab showed encouraging antitumor activity and safety in a phase 1b trial involving patients with unresectable …
RK Kelley - New England Journal of Medicine, 2020 - Mass Medical Soc
More than a decade ago, sorafenib became the first systemic therapy that conferred a meaningful survival benefit in the treatment of advanced hepatocellular carcinoma. 1 Since …
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death and its incidence is increasing globally. Around 50% of …