Utility of polygenic scores for differentiating diabetes diagnosis among patients with atypical phenotypes of diabetes

LK Billings, Z Shi, J Wei, AS Rifkin… - The Journal of …, 2024 - academic.oup.com
Context Misclassification of diabetes type occurs in people with atypical presentations of
type 1 diabetes (T1D) or type 2 diabetes (T2D). Although current clinical guidelines suggest …

[HTML][HTML] Comparison of Insulin-Treated Patients with Ambiguous Diabetes Type with Definite Type 1 and Type 2 Diabetes Mellitus Subjects: A Clinical Perspective

I Laspe, JJ Meier, MA Nauck - Diabetes & Metabolism Journal, 2023 - ncbi.nlm.nih.gov
In clinical practice, the distinction between type 1 diabetes mellitus (T1DM) and type 2
diabetes mellitus (T2DM) can be challenging, leaving patients with “ambiguous” diabetes …

A type 1 diabetes polygenic score is not associated with prevalent type 2 diabetes in large population studies

S Srinivasan, P Wu, JM Mercader… - Journal of the …, 2023 - academic.oup.com
Context Both type 1 diabetes (T1D) and type 2 diabetes (T2D) have significant genetic
contributions to risk and understanding their overlap can offer clinical insight. Objective We …

Type 2 diabetes family history as a significant index on the clinical heterogeneity differentiation in type 1 diabetes

Q Wang, Y Chen, Y Xie, Y Xia, Z Xie… - The Journal of …, 2023 - academic.oup.com
Context Family history of type 2 diabetes (T2D) is an important but neglected parameter;
however, its role in identifying the heterogeneity and subtypes of type 1 diabetes (T1D) …

Type 1 diabetes genetic risk score: a novel tool to discriminate monogenic and type 1 diabetes

KA Patel, RA Oram, SE Flanagan, E De Franco… - Diabetes, 2016 - Am Diabetes Assoc
Distinguishing patients with monogenic diabetes from those with type 1 diabetes (T1D) is
important for correct diagnosis, treatment, and selection of patients for gene discovery …

[HTML][HTML] Type 2 diabetes: multiple genes, multiple diseases

MS Udler - Current diabetes reports, 2019 - Springer
Abstract Purpose of Review Type 2 diabetes (T2D), which accounts for the vast majority of
diabetes cases, is essentially a diagnosis of exclusion in current clinical practice. Therefore …

[HTML][HTML] Phenotypic and genetic classification of diabetes

AJ Deutsch, E Ahlqvist, MS Udler - Diabetologia, 2022 - Springer
The historical subclassification of diabetes into predominantly types 1 and 2 is well
appreciated to inadequately capture the heterogeneity seen in patient presentations …

Current genetic data do not improve the prediction of type 2 diabetes mellitus: the CoLaus study

R Schmid, P Vollenweider, F Bastardot… - The Journal of …, 2012 - academic.oup.com
Context: Several genetic risk scores to identify asymptomatic subjects at high risk of
developing type 2 diabetes mellitus (T2DM) have been proposed, but it is unclear whether …

A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults

RA Oram, K Patel, A Hill, B Shields… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE With rising obesity, it is becoming increasingly difficult to distinguish between
type 1 diabetes (T1D) and type 2 diabetes (T2D) in young adults. There has been …

[HTML][HTML] Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India

JW Harrison, DSP Tallapragada, A Baptist, SA Sharp… - Scientific Reports, 2020 - nature.com
Abstract Type 1 diabetes (T1D) is a significant problem in Indians and misclassification of
T1D and type 2 diabetes (T2D) is a particular problem in young adults in this population due …