Corneal nerves in health and disease

BS Shaheen, M Bakir, S Jain - Survey of ophthalmology, 2014 - Elsevier
Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

Corneal nerves in health and disease

MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

Role of corneal nerves in ocular surface homeostasis and disease

M Labetoulle, C Baudouin, M Calonge… - Acta …, 2019 - Wiley Online Library
Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

Neurotrophic factors and corneal nerve regeneration

M Sacchetti, A Lambiase - Neural regeneration research, 2017 - journals.lww.com
The cornea has unique features that make it a useful model for regenerative medicine
studies. It is an avascular, transparent, densely innervated tissue and any pathological …

Understanding the pathogenesis of neurotrophic keratitis: the role of corneal nerves

L Mastropasqua, G Massaro‐Giordano… - Journal of cellular …, 2017 - Wiley Online Library
Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by
trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium …

Corneal nerves: structure, contents and function

LJ Müller, CF Marfurt, F Kruse, TMT Tervo - Experimental eye research, 2003 - Elsevier
This review provides a comprehensive analysis of the structure, neurochemical content, and
functions of corneal nerves, with special emphasis on human corneal nerves. A revised …

Corneal confocal microscopy: ready for prime time

IN Petropoulos, G Ponirakis, A Khan… - Clinical and …, 2020 - Taylor & Francis
Corneal confocal microscopy is a non‐invasive ophthalmic imaging modality, which was
initially used for the diagnosis and management of corneal diseases. However, over the last …

Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves

MA Stepp, G Tadvalkar, R Hakh, S Pal‐Ghosh - Glia, 2017 - Wiley Online Library
The eye is innervated by neurons derived from both the central nervous system and
peripheral nervous system (PNS). While much is known about retinal neurobiology and …

The two-faced effects of nerves and neuropeptides in corneal diseases

RML Vitar, P Rama, G Ferrari - Progress in Retinal and Eye Research, 2022 - Elsevier
Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

[HTML][HTML] Focus: Sensory biology and pain: Corneal innervation and sensation: The eye and beyond

AY Yang, J Chow, J Liu - The Yale journal of biology and medicine, 2018 - ncbi.nlm.nih.gov
The cornea is one of the most densely innervated and sensitive tissues in the body. In
addition to their important sensory functions, corneal nerves induce reflex tear production …