A thyroid hormone receptor that is required for the development of green cone photoreceptors

L Ng, JB Hurley, B Dierks, M Srinivas, C Saltó… - Nature …, 2001 - nature.com
Color vision is facilitated by distinct populations of cone photoreceptors in the retina. In
rodents, cones expressing different opsin photopigments are sensitive to middle (M,'green') …

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

KC Eldred, SE Hadyniak, KA Hussey, B Brenerman… - Science, 2018 - science.org
INTRODUCTION Cone photoreceptors in the human retina enable daytime, color, and high-
acuity vision. The three subtypes of human cones are defined by the visual pigment that they …

Transcriptional control of cone photoreceptor diversity by a thyroid hormone receptor

M Aramaki, X Wu, H Liu, Y Liu… - Proceedings of the …, 2022 - National Acad Sciences
Cone photoreceptor diversity allows detection of wavelength information in light, the first
step in color (chromatic) vision. In most mammals, cones express opsin photopigments for …

Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina

MR Roberts, M Srinivas, D Forrest… - Proceedings of the …, 2006 - National Acad Sciences
Most mammals have two types of cone photoreceptors, which contain either medium
wavelength (M) or short wavelength (S) opsin. The number and spatial organization of cone …

Transient expression of thyroid hormone nuclear receptor TRβ2 sets S opsin patterning during cone photoreceptor genesis

ML Applebury, F Farhangfar… - … dynamics: an official …, 2007 - Wiley Online Library
Cone photoreceptors in the murine retina are patterned by dorsal repression and ventral
activation of S opsin. TRβ2, the nuclear thyroid hormone receptor β isoform 2, regulates …

A neuronal circuit for colour vision based on rod–cone opponency

M Joesch, M Meister - Nature, 2016 - nature.com
In bright light, cone-photoreceptors are active and colour vision derives from a comparison
of signals in cones with different visual pigments. This comparison begins in the retina …

Light adaptation in cone vision involves switching between receptor and post-receptor sites

FA Dunn, MJ Lankheet, F Rieke - Nature, 2007 - nature.com
We see over an enormous range of mean light levels, greater than the range of output
signals retinal neurons can produce. Even highlights and shadows within a single visual …

Thyroid hormone controls cone opsin expression in the retina of adult rodents

A Glaschke, J Weiland, D Del Turco… - Journal of …, 2011 - Soc Neuroscience
Mammalian retinas display an astonishing diversity in the spatial arrangement of their
spectral cone photoreceptors, probably in adaptation to different visual environments. Opsin …

Gene therapy for red–green colour blindness in adult primates

K Mancuso, WW Hauswirth, Q Li, TB Connor… - Nature, 2009 - nature.com
Red–green colour blindness, which results from the absence of either the long-(L) or the
middle-(M) wavelength-sensitive visual photopigments, is the most common single locus …

Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate

NB Haider, SG Jacobson, AV Cideciyan, R Swiderski… - Nature …, 2000 - nature.com
Hereditary human retinal degenerative diseases usually affect the mature photoreceptor
topography by reducing the number of cells through apoptosis, resulting in loss of visual …