Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis

R Wilson, MG Bossong, E Appiah-Kusi, N Petros… - Translational …, 2019 - nature.com
Accumulating evidence points towards the antipsychotic potential of cannabidiol. However,
the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain …

Effect of cannabidiol on medial temporal, midbrain, and striatal dysfunction in people at clinical high risk of psychosis: a randomized clinical trial

S Bhattacharyya, R Wilson, E Appiah-Kusi… - Jama …, 2018 - jamanetwork.com
Importance Cannabidiol (CBD) has antipsychotic effects in humans, but how these are
mediated in the brain remains unclear. Objective To investigate the neurocognitive …

[HTML][HTML] The impact of cannabidiol on human brain function: a systematic review

A Batalla, J Bos, A Postma, MG Bossong - Frontiers in pharmacology, 2021 - frontiersin.org
Background: Accumulating evidence suggests that the non-intoxicating cannabinoid
compound cannabidiol (CBD) may have antipsychotic and anxiolytic properties, and thus …

The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers

W Lawn, J Hill, C Hindocha, J Yim… - Journal of …, 2020 - journals.sagepub.com
Background: Cannabidiol has potential therapeutic benefits for people with psychiatric
disorders characterised by reward function impairment. There is existing evidence that …

A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis

C Davies, R Wilson, E Appiah-Kusi… - Translational …, 2020 - nature.com
Emotional dysregulation and anxiety are common in people at clinical high risk for psychosis
(CHR) and are associated with altered neural responses to emotional stimuli in the striatum …

Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis

A O'Neill, R Wilson, G Blest-Hopley… - Psychological …, 2021 - cambridge.org
BackgroundRecent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient
present in cannabis extract, has an antipsychotic effect in people with established psychosis …

Cannabinoids, reward processing, and psychosis

B Gunasekera, K Diederen, S Bhattacharyya - Psychopharmacology, 2022 - Springer
Background Evidence suggests that an overlap exists between the neurobiology of
psychotic disorders and the effects of cannabinoids on neurocognitive and neurochemical …

Cannabidiol modulation of hippocampal glutamate in early psychosis

A O'Neill, L Annibale, G Blest-Hopley… - Journal of …, 2021 - journals.sagepub.com
Background: Emerging evidence supports the antipsychotic effect of cannabidiol, a non-
intoxicating component of cannabis, in people with psychosis. Preclinical findings suggest …

Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol

FV Gomes, R Llorente, EA Del Bel, MP Viveros… - Schizophrenia …, 2015 - Elsevier
NMDA receptor hypofunction could be involved, in addition to the positive, also to the
negative symptoms and cognitive deficits found in schizophrenia patients. An increasing …

The effects of cannabidiol on persecutory ideation and anxiety in a high trait paranoid group

H Hundal, R Lister, N Evans, A Antley… - Journal of …, 2018 - journals.sagepub.com
Background: Previous studies have suggested that cannabidiol has anxiolytic and
antipsychotic properties, raising hopes that cannabidiol will translate to the psychiatric clinic …