[PDF][PDF] The Nephroblastoma Oncosimulator: Clinical adaptation for patients of distinct histologic profiles using high performance computing

F Panagiotidou - 2022 - dspace.lib.ntua.gr
The Oncosimulator is a top-down discrete entity-discrete event model for multiscale cancer
modeling, that represents the tumor in silico as a 3D matrix of voxels and utilizes the …

The technologically integrated oncosimulator: combining multiscale cancer modeling with information technology in the in silico oncology context

G Stamatakos, D Dionysiou, A Lunzer… - IEEE Journal of …, 2013 - ieeexplore.ieee.org
This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …

Towards in silico oncology: adapting a four dimensional nephroblastoma treatment model to a clinical trial case based on multi-method sensitivity analysis

EC Georgiadi, DD Dionysiou, N Graf… - Computers in Biology …, 2012 - Elsevier
In the past decades a great progress in cancer research has been made although medical
treatment is still widely based on empirically established protocols which have many …

Development of the p-medicine oncosimulator as a parallel treatment support system

M Blazewicz, EC Georgiadi, J Pukacki… - Proceedings of the …, 2014 - ieeexplore.ieee.org
The purpose of this research was the parallelization of the Wilms' Oncosimulator, an
integrated cancer treatment support system modeling the growth of nephroblastoma tumors …

'In silico'oncology for clinical decision making in the context of nephroblastoma

N Graf, A Hoppe, E Georgiadi, R Belleman… - Klinische …, 2009 - thieme-connect.com
The present paper outlines the initial version of the ACGT (Advancing Clinico-Genomic
Trials)–an Integrated Project, partly funded by the EC (FP6-2005-IST-026996) I …

The" Oncosimulator": a multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical …

GS Stamatakos, DD Dionysiou, NM Graf… - 2007 29th Annual …, 2007 - ieeexplore.ieee.org
The" Oncosimulator" is at the same time a concept of multilevel integrative cancer and
(treatment affected) normal tissue biology, an algorithmic construct and a software tool which …

Tumor growth simulation profiling

C Jean-Quartier, F Jeanquartier, D Cemernek… - … Technology in Bio-and …, 2016 - Springer
Cancer constitutes a condition and is referred to a group of numerous different diseases, that
are characterized by uncontrolled cell growth. Tumors, in the broader sense, are described …

Exploiting clinical trial data drastically narrows the window of possible solutions to the problem of clinical adaptation of a multiscale cancer model

GS Stamatakos, EC Georgiadi, N Graf, EA Kolokotroni… - PLoS …, 2011 - journals.plos.org
The development of computational models for simulating tumor growth and response to
treatment has gained significant momentum during the last few decades. At the dawn of the …

▪ In Silico Oncology: Part I—Clinically Oriented Cancer Multilevel Modeling Based on Discrete Event Simulation

GS STAMATAKOS - Multiscale Cancer Modeling, 2010 - taylorfrancis.com
INTRODUCTION Most cancer modeling techniques developed up to now adopt the
straightforward “bottom-up” approach, focusing on the better understanding and …

In Silico oncology: a top-down multiscale simulator of cancer dynamics. Studying the effect of symmetric stem cell division on the cellular constitution of a tumour

GS Stamatakos, E Kolokotroni, D Dionysiou… - World Congress on …, 2010 - Springer
The tremendous rate of accumulation of experimentally and clinically extracted knowledge
concerning cancer at all levels of biocomplexity dictates the development of integrative in …