[HTML][HTML] Disentangling mitochondria in Alzheimer's disease

A Johri - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease

SN Rai, C Singh, A Singh, MP Singh, BK Singh - Molecular Neurobiology, 2020 - Springer
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

[HTML][HTML] Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease

C Sharma, S Kim, Y Nam, UJ Jung, SR Kim - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …

Mechanisms of mitochondrial dysfunction in Alzheimer's disease

C Cadonic, MG Sabbir, BC Albensi - Molecular neurobiology, 2016 - Springer
Mitochondria are the primary source for energy generation in the cell, which manifests itself
in the form of the adenosine triphosphate (ATP). Nicotinamide dinucleotide (NADH) …

[HTML][HTML] Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Alzheimer's disease: the role of mitochondrial dysfunction and potential new therapies

ZL Hawking - Bioscience Horizons: The International Journal of …, 2016 - academic.oup.com
Alzheimer's disease (AD) is characterized by neuronal loss and gradual cognitive
impairment. AD is the leading cause of dementia worldwide and the incidence is increasing …

[HTML][HTML] Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Mitochondrial biology in Alzheimer's disease pathogenesis

MF Galindo, I Ikuta, X Zhu… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 114, 933–945. Abstract Despite the increasing knowledge of
Alzheimer's disease (AD) management with novel pharmacologic agents, most of them are …

Targeting mitochondria in Alzheimer disease: rationale and perspectives

C Lanzillotta, F Di Domenico, M Perluigi, DA Butterfield - CNS drugs, 2019 - Springer
A decline in mitochondrial function plays a key role in the aging process and increases the
incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the …

Mitochondrial oxidative damage in aging and Alzheimer′ s disease: implications for mitochondrially targeted antioxidant therapeutics

PH Reddy - BioMed Research International, 2006 - Wiley Online Library
The overall aim of this article is to review current therapeutic strategies for treating AD, with a
focus on mitochondrially targeted antioxidant treatments. Recent advances in molecular …