A point-of-care single nucleotide variation assay based on strand-displacement-triggered recombinase polymerase amplification

L Zhang, L Xu, J Zhang, W Wang, Y Huang… - Sensors and Actuators B …, 2024 - Elsevier
The single nucleotide variation (SNV) assay holds significant value in the diagnosis of
genetic diseases. However, the wide application of SNV analysis in clinics meets many …

A universal locked nucleic acid-integrated X-shaped DNA probe design for amplified fluorescence detection of single-nucleotide variant

F Wu, M Chen, J Lan, Y Xia, M Liu, W He, C Li… - Sensors and Actuators B …, 2017 - Elsevier
Single-nucleotide variant (SNV) is crucial in clinical diagnostics as a useful biomarker,
because it is closely associated with many diseases, such as genetic disorders and tumors …

A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity

X Chen, D Zhou, H Shen, H Chen, W Feng, G Xie - Scientific Reports, 2016 - nature.com
Single-nucleotide variation (SNV) is a crucial biomarker for drug resistance-related detection
in cancer and bacterial infection. However, the unintended binding of DNA probes limits the …

Molecular dynamics simulation‐guided toehold mediated strand displacement probe for single‐nucleotide variants detection

L Zhang, J Chen, M He, X Su - Exploration, 2022 - Wiley Online Library
Single nucleotide variant (SNV) has become an emerging biomarker for various diseases
such as cancers and infectious diseases. Toehold‐mediated strand displacement (TMSD) …

Recent advances in enzyme-free and enzyme-mediated single-nucleotide variation assay in vitro

E Xiong, P Liu, R Deng, K Zhang… - National Science …, 2024 - academic.oup.com
Single-nucleotide variants (SNVs) are the most common type variation of sequence
alterations at a specific location in the genome, thus involving significant clinical and …

High fidelity SNP genotyping using sequence-specific primer elongation and fluorescence correlation spectroscopy

K Hori, WS Shin, C Hemmi, T Toyo-Oka… - Current …, 2003 - ingentaconnect.com
Reliable, efficient and cost-effective modalities are urgently needed for mass screening of
gene mutations. Previous reports have shown that SSCP or genechip methods require …

Competitive activation cross amplification combined with smartphone-based quantification for point-of-care detection of single nucleotide polymorphism

J Wen, H Gou, S Wang, Q Lin, K Chen, Y Wu… - Biosensors and …, 2021 - Elsevier
In this study, we firstly propose a novel smartphone-assisted visualization SNP genotyping
method termed competitive activation cross amplification (CACA). The mutation detection …

Emerging technologies for hybridization based single nucleotide polymorphism detection

K Knez, D Spasic, KPF Janssen, J Lammertyn - Analyst, 2014 - pubs.rsc.org
Detection of single nucleotide polymorphisms (SNPs) is a crucial challenge in the
development of a novel generation of diagnostic tools. Accurate detection of SNPs can …

Endonuclease IV-regulated DNAzyme motor for universal single-nucleotide variation discrimination

Z Zhang, Y Hu, W Yuan, M Hu, Y Deng… - Analytical …, 2021 - ACS Publications
Single-nucleotide variation (SNV) detection plays significant roles in disease diagnosis and
treatment. Generally, auxiliary probe, restricted design rules, complicated detection system …

Fluorometric detection of single-nucleotide mutations using tandem gene amplification

DM Kim, J Seo, DW Kim, W Jeong, SH Hwang… - Sensors and Actuators B …, 2020 - Elsevier
Sensitive and accurate identification of single-nucleotide mutations (SNMs) has become
crucial in the field of molecular diagnosis and personalized medicine. Here, we developed a …