Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis
Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …
Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk
Importance Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically
distinct entities, there is a possibility of a pathological overlap, with some genome-wide …
distinct entities, there is a possibility of a pathological overlap, with some genome-wide …
[HTML][HTML] Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders
VK Ramanan, AJ Saykin - American journal of neurodegenerative …, 2013 - ncbi.nlm.nih.gov
The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
Alzheimer's disease (AD) and related dementias are a major public health challenge and
present a therapeutic imperative for which we need additional insight into molecular …
present a therapeutic imperative for which we need additional insight into molecular …
Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …
have identified loci that harbor risk variants for neurodegenerative diseases, including …
[HTML][HTML] Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities
The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and
neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from …
neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from …
Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms
Alzheimer's disease (AD) is a genetically complex, multifactorial neurodegenerative
disease. It affects more than 45 million people worldwide and currently remains untreatable …
disease. It affects more than 45 million people worldwide and currently remains untreatable …
The molecular and neuropathological consequences of genetic risk for Alzheimer's dementia
Alzheimer's dementia commonly impacts the health of older adults and lacks any
preventative therapy. While Alzheimer's dementia risk has a substantial genetic component …
preventative therapy. While Alzheimer's dementia risk has a substantial genetic component …
Genome-wide association studies for Alzheimer's disease: bigger is not always better
V Escott-Price, J Hardy - Brain Communications, 2022 - academic.oup.com
As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …
identified inevitably increase. One welcomes this if it allows the better delineation of the …
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
loci associated with Alzheimer's disease (AD), but the genes responsible for these …