Ageing is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. Despite rapid advances over recent years …

Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …

Aging is associated with complex molecular and cellular processes that are poorly
understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to …

Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

Organismal ageing results from interlinked molecular changes in multiple organs over time.
The study of ageing at the molecular level is complicated by varying decay characteristics …

Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals
are composed of distinct cell type identities and tissue environments, but the influence of …

Aging is a complex process that affects multiple organs. Modeling aging and age-related
diseases in the lab is challenging because classical vertebrate models have relatively long …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …