The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

Cannabidiol and epilepsy: Rationale and therapeutic potential

A Leo, E Russo, M Elia - Pharmacological research, 2016 - Elsevier
Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic
response for patients with epilepsy remains still poor. Unfortunately, besides several …

[HTML][HTML] Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures

NA Jones, SE Glyn, S Akiyama, TDM Hill, AJ Hill… - Seizure, 2012 - Elsevier
Cannabis sativa has been associated with contradictory effects upon seizure states despite
its medicinal use by numerous people with epilepsy. We have recently shown that the …

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models

PH Patra, M Barker‐Haliski, HS White, BJ Whalley… - …, 2019 - Wiley Online Library
Objective Epilepsy is a progressive neurological disease characterized by recurrent
seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol …

The utility of cannabidiol in the treatment of refractory epilepsy

DS Reddy - Clinical Pharmacology & Therapeutics, 2017 - Wiley Online Library
Cannabis‐derived cannabinoids such as cannabidiol (CBD) have anticonvulsant properties.
Recently, there has been an emerging interest in the use of CBD‐enriched products for …

Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo

NA Jones, AJ Hill, I Smith, SA Bevan… - … of Pharmacology and …, 2010 - ASPET
Plant-derived cannabinoids (phytocannabinoids) are compounds with emerging therapeutic
potential. Early studies suggested that cannabidiol (CBD) has anticonvulsant properties in …

Cannabidiol therapy for refractory epilepsy and seizure disorders

V Golub, DS Reddy - Cannabinoids and neuropsychiatric disorders, 2021 - Springer
Cannabis-derived cannabinoids have neuroactive properties. Recently, there has been
emerging interest in the use of cannabidiol (CBD)-enriched products for treatment of drug …

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels

LR Vilela, IV Lima, ÉB Kunsch, HPP Pinto… - Epilepsy & Behavior, 2017 - Elsevier
Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits
experimental seizures in animal models and alleviates certain types of intractable epilepsies …

The case for assessing cannabidiol in epilepsy

MR Cilio, EA Thiele, O Devinsky - Epilepsia, 2014 - Wiley Online Library
Intractable epilepsies have an extraordinary impact on cognitive and behavioral function
and quality of life, and the treatment of seizures represents a challenge and a unique …

Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies

DS Reddy - Experimental neurology, 2023 - Elsevier
Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …