We carried out the first analysis of alternative splicing complexity in human tissues using
mRNA-Seq data. New splice junctions were detected in∼ 20% of multiexon genes, many of …

Alternative splicing is widely recognized for its roles in regulating genes and creating gene
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …

Thousands of alternative exons are spliced out of messenger RNA to increase protein
diversity. High‐throughput sequencing of short cDNA fragments (RNA‐seq) generates a …

Alternative splicing shapes mammalian transcriptomes, with many RNA molecules
undergoing multiple distant alternative splicing events. Comprehensive transcriptome …

Background Alternative pre-mRNA splicing (AS) is widely used by higher eukaryotes to
generate different protein isoforms in specific cell or tissue types. To compare AS events …

While the majority of multiexonic human genes show some evidence of alternative splicing,
it is unclear what fraction of observed splice forms is functionally relevant. In this study, we …

Tress and colleagues proposed that only a minor fraction of splice variants detected in
transcriptome profiling data are translated and, therefore, that most splice variants have little …

Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development,
physiology, and disease, and more than half of human genes are alternatively spliced. To …

Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes
have alternative splice forms, suggesting that alternative splicing is one of the most …

High-throughput RNA sequencing (RNA-seq) has revealed an enormous complexity of
alternative splicing (AS) across diverse cell and tissue types. However, it is currently …