Challenges and opportunities from targeting inflammatory responses to SARS-CoV-2 infection: a narrative review

V Lariccia, S Magi, T Serfilippi, M Toujani… - Journal of Clinical …, 2020 - mdpi.com
The novel coronavirus disease 2019 (COVID-19) is a global pandemic that continues to
sweep across the world, posing an urgent need for effective therapies and prevention of the …

Inflammatory pathways and potential therapies for COVID-19: A mini review

AM Dabbish, N Yonis, M Salama… - European Journal …, 2021 - journals.sagepub.com
The public health crisis of the novel coronavirus disease (COVID-19) is alarming since
January 2020. COVID-19 genome (SARS-CoV-2) is related to other highly pathogenic …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

COVID-19 as an acute inflammatory disease

RH Manjili, M Zarei, M Habibi… - The journal of immunology, 2020 - journals.aai.org
Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by the virus severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

[HTML][HTML] Recent insight into SARS-CoV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

S Lega, S Naviglio, S Volpi, A Tommasini - Vaccines, 2020 - mdpi.com
As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great
effort is being made to understand the disease pathogenesis and host factors that …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome
coronavirus 2 presents with a spectrum of clinical manifestations from asymptomatic or mild …

COVID-19: Immunology and treatment options

S Felsenstein, JA Herbert, PS McNamara… - Clinical …, 2020 - Elsevier
The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of escaping innate …

Pathogenesis guided therapeutic management of COVID-19: an immunological perspective

A Kumar, P Prasoon, PS Sekhawat… - International Reviews …, 2021 - Taylor & Francis
Lack of standardized therapeutic approaches is arguably the significant contributor to the
high burden of mortality observed in the ongoing pandemic of the Coronavirus disease …

Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter cytokine …

AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …