Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

The innate immune system has a key role in the mammalian immune response. Recent
research has demonstrated that mitochondria participate in a broad range of innate immune …

Mitochondria are versatile organelles and essential components of numerous biological
processes such as energy metabolism, signal transduction, and cell fate determination. In …

Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

A growing literature indicates that mitochondria are key participants in innate immune
pathways, functioning as both signaling platforms and contributing to effector responses. In …

Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of
diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in …

Upon microbial infection, cells of the innate immune system undergo profound metabolic
reprogramming in order to eradicate pathogens, promote inflammation, and eventually …

Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles.
In the past two decades, mitochondria have emerged as signaling organelles that contribute …

Canonical functions of mitochondria include the regulation of cellular survival, orchestration
of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling …

Mitochondria, the dynamic organelles and power house of eukaryotic cells function as
metabolic hubs of cells undergoing continuous cycles of fusion and fission. Recent findings …