Recent progress in phospholipase A2 research: from cells to animals to humans

M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Phospholipase A2 isoforms: a perspective

S Chakraborti - Cellular signalling, 2003 - Elsevier
Several new PLA2s have been identified based on their nucleotide gene sequences. They
were classified mainly into three groups: cytosolic PLA2 (cPLA2), secretary PLA2 (sPLA2) …

Updating Phospholipase A2 Biology

M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Novel functions of phospholipase A2s: Overview

M Murakami - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2019 - Elsevier
Abstract The phospholipase A 2 (PLA 2) family comprises a group of lipolytic enzymes that
typically hydrolyze the sn-2 position of (glycerol) phospholipids to give rise to fatty acids and …

Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s

Y Kita, T Ohto, N Uozumi, T Shimizu - … (BBA)-Molecular and Cell Biology of …, 2006 - Elsevier
Phospholipase A2 (PLA2)(EC 3.1. 1.4) catalyzes hydrolysis of the sn-2 ester bond of
glycerophospholipids. The enzyme is essential for the production of two classes of lipid …

Emerging roles of secreted phospholipase A2 enzymes: an update

M Murakami, G Lambeau - Biochimie, 2013 - Elsevier
Phospholipase A2 (PLA2) enzymes catalyze the hydrolysis of the sn-2 position of
glycerophospholipids to produce free fatty acids and lysophospholipids. More than one third …

Cytosolic phospholipase A2: physiological function and role in disease

CC Leslie - Journal of lipid research, 2015 - ASBMB
The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

Secreted phospholipase A2 revisited

M Murakami, Y Taketomi, H Sato… - The journal of …, 2011 - academic.oup.com
Abstract Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of
glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 …

The roles of the secreted phospholipase A2 gene family in immunology

M Murakami, K Yamamoto, Y Miki, R Murase… - Advances in …, 2016 - Elsevier
Within the phospholipase A 2 (PLA 2) family that hydrolyzes phospholipids to yield fatty
acids and lysophospholipids, secreted PLA 2 (sPLA 2) enzymes comprise the largest group …

Cytosolic phospholipase A2: biochemical properties and physiological roles

T Shimizu, T Ohto, Y Kita - IUBMB life, 2006 - Wiley Online Library
Phosphatidylcholine (PC) is a major constituent of biological membranes and a component
of serum lipoproteins and pulmonary surfactants. The PC and other glycerophospholipid …