EBV and apoptosis: the viral master regulator of cell fate?

L Fitzsimmons, GL Kelly - Viruses, 2017 - mdpi.com
Epstein–Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma
(BL), and is now known to be a contributory factor in 1–2% of all cancers, for which there are …

Epstein-Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis

M Altmann, W Hammerschmidt - PLoS Biology, 2005 - journals.plos.org
DNA viruses such as herpesviruses are known to encode homologs of cellular antiapoptotic
viral Bcl-2 proteins (vBcl-2s), which protect the virus from apoptosis in its host cell during …

Three restricted forms of Epstein–Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells

GL Kelly, AE Milner, GS Baldwin… - Proceedings of the …, 2006 - National Acad Sciences
Epstein–Barr virus (EBV), a human herpesvirus, transforms B cell growth in vitro through
expressing six virus-coded Epstein–Barr nuclear antigens (EBNAs) and two latent …

Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells

Q Fu, C He, Z Mao - Journal of Zhejiang University SCIENCE B, 2013 - Springer
Abstract Epstein-Barr virus (EBV), a human gammaherpesvirus carried by more than 90% of
the world's population, is associated with malignant tumors such as Burkitt's lymphoma (BL) …

Insights into the evolution of lymphomas induced by Epstein–Barr virus

D Vereide, B Sugden - Advances in cancer research, 2010 - Elsevier
Epstein–Barr virus (EBV) encodes a wealth of oncogenic instructions, including the abilities
to drive a resting normal B cell to proliferate and to override apoptotic stimuli. EBV is found in …

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

AM Price, J Dai, Q Bazot, L Patel, PA Nikitin… - Elife, 2017 - elifesciences.org
Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV
expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to …

Epstein–barr virus history and pathogenesis

H Yu, ES Robertson - Viruses, 2023 - mdpi.com
Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish
asymptomatic life-long persistence. It is associated with a large spectrum of diseases …

Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma

IK Ruf, PW Rhyne, H Yang, CM Borza… - … and cellular biology, 1999 - Am Soc Microbiol
Abstract Loss of the Epstein-Barr virus (EBV) genome from Akata Burkitt lymphoma (BL)
cells is coincident with a loss of malignant phenotype, despite the fact that Akata and other …

Lymphomas differ in their dependence on Epstein-Barr virus

DT Vereide, B Sugden - Blood, The Journal of the American …, 2011 - ashpublications.org
Epstein-Barr virus (EBV) encodes oncogenic information and, oftentimes concomitant with
host immunosuppression, gives rise to malignancies in all major categories of lymphoma …

Regulation of the latent-lytic switch in Epstein–Barr virus

SC Kenney, JE Mertz - Seminars in cancer biology, 2014 - Elsevier
Epstein–Barr virus (EBV) infection contributes to the development of several different types
of human malignancy, including Burkitt lymphoma, Hodgkin lymphoma, and …