Introduction: Self-assembling peptides are synthetic, amphipathic peptides that may serve
as new hemostatic agents. The first-generation hemostat TDM-621 has been used in clinical …

Objective: One of the leading causes of death following traumatic injury is exsanguination.
Biological material-based hemostatic agents such as fibrin, thrombin, and albumin have a …

Abstract Background Self‐assembling peptides (TDMs) comprise synthetic amphipathic
peptides that immediately react to changes in pH and/or inorganic salts to transform into a …

Uncontrolled traumatic bleeding can lead to death due to excessive blood loss within
minutes. Early intervention is crucial to save lives, making timely and effective hemostasis is …

Background A synthetic peptide 'TDM-623'is a promising hemostatic material for endoscopic
surgery in the gastrointestinal tract. However, its stability under gastric/pancreatic secretion …

Intra-operative and postoperative bleeding is a major concern in surgical procedures for
patients taking anticoagulant medications, or where anticoagulants are used to prevent …

Blood plays an essential role in the human body. Hemorrhage is a critical cause of both
military and civilian casualties. The human body has its own hemostatic mechanism that …

Trauma requires immediate hemostasis during primary care, as well as durable hemostasis
that can withstand dynamic wound exposure. Although current hemostatic materials can …

Background Hemorrhage, a sudden and severe leakage of blood due to the disruption of
blood vessels, is one of the most common causes of death from injuries worldwide. Severe …

Wide interest in new hemostatic approaches has stemmed from unmet needs in the hospital
and on the battlefield. Many current commercial hemostatic agents fail to fulfill the design …