Deposition of polydisperse particles representing nasal spray application in a human nasal
cavity was performed under transient breathing profiles of sniffing, constant flow, and breath …

Effective nasal drug delivery is highly dependent on the delivery of drug from the nasal spray
device. Atomisation of liquid spray occurs through the internal atomizer that can produce …

Many studies suggest limited effectiveness of spray devices for nasal drug delivery due
primarily to high deposition and clearance at the front of the nose. Here, nasal spray …

Particle depositional studies from nasal sprays are important for efficient drug delivery. The
main influences on deposition involve the nasal cavity geometry and the nasal spray device …

Background: Knowledge of the regional deposition of inhaled particles in the nose is
important for drug delivery and assessment of the toxicity of inhaled materials. In this study …

In this study, the effects of nasal drug delivery device and the spray nozzle orientation on
sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior …

Experimental images from particle/droplet image analyser (PDIA) and particle image
velocimetry (PIV) imaging techniques of particle formation from a nasal spray device were …

The human nasal passages effectively filter particles from inhaled air. This prevents harmful
pollutants from reaching susceptible pulmonary airways, but may leave the nasal mucosa …

Validating numerical models against experimental models of nasal spray deposition is
challenging since many aspects must be considered. That being said, it is a critical step in …

The present work examines regional deposition within the nose for nasal sprays over a large
and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult …