Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive
intratumoral CD8+ T cell activation. Using multiple strategies, we identified a critical role for …

It is well understood that antigen-presenting cells (APCs) within tumors typically do not
maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse …

To achieve in situ tumor antigen uptake and presentation, intratumoral administration of ex
vivo-generated, gene-modified murine bone marrow-derived dendritic cells (DC) was used …

Tumors harbor several populations of dendritic cells (DCs) with the ability to prime tumor-
specific T cells. However, these T cells mostly fail to differentiate into armed effectors and are …

AT cell-inflamed tumor microenvironment is characterized by the accumulation and local
activation of CD8+ T cells and Bat3-lineage dendritic cells, which together are associated …

The tumor microenvironment is characterized by regulatory T cells, type II macrophages,
myeloid-derived suppressor cells, and other immunosuppressive cells that promote …

Dendritic cells (DCs) are very potent antigen-presenting cells and play critical roles in
regulating immune responses in cancer. The migrating of DCs from the tumor site to the …

Background The conventional type 1 dendritic cell subset (cDC1) is indispensable for tumor
immune responses and the efficacy of immune checkpoint inhibitor (ICI) therapies in animal …

Background Increasing infiltration of CD8+ T cells within tumor tissue predicts a better
prognosis and is essential for response to checkpoint blocking therapy. Furthermore, current …

In this issue of Immunity, Chow et al.(2019) show that the CXCR3-CXCL9 axis is required for
reinvigoration of intratumoral CD8+ T cell responses in response to PD-1 blockade and …