A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the
cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs …

Mapping protein–protein interactions is an invaluable tool for understanding protein
function. Here, we report the first large‐scale study of protein–protein interactions in human …

Mass spectrometry is currently at the forefront of technologies for mapping protein–protein
interactions, as it is a highly sensitive technique that enables the rapid identification of …

While the genomic revolution has dramatically accelerated the discovery of disease-
associated genes, the functional characterization of the corresponding proteins lags behind …

The study of protein-protein interactions by mass spectrometry is an increasingly important
part of post-genomics strategies to understand protein function. A variety of mass …

Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …

Mass spectrometry (MS)-based proteomics has significantly contributed to the development
of systems biology, a new paradigm for the life sciences in which biological processes are …

During the past decades, mass spectrometry (MS)-based proteomics has become an
important technology to identify protein–protein interactions (PPIs). The application of a …

In the life sciences, a new paradigm is emerging that places networks of interacting
molecules between genotype and phenotype. These networks are dynamically modulated …