[HTML][HTML] Recent advances in drug discovery for triple-negative breast cancer treatment

D Masci, C Naro, M Puxeddu, A Urbani, C Sette… - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is one of the most heterogeneous and aggressive
breast cancer subtypes with a high risk of death on recurrence. To date, TNBC is very …

Advances in small-molecule drug discovery for triple-negative breast cancer

N Fosu-Mensah, MS Peris, HP Weeks… - Future medicinal …, 2015 - Taylor & Francis
Triple-negative breast cancer (TNBC) is a subtype of poor prognosis, highly invasive and
difficult-to-treat breast cancers accounting for approximately 15% of clinical cases. Given the …

Novel therapeutic strategies for patients with triple-negative breast cancer

JF Zhang, J Liu, Y Wang, B Zhang - OncoTargets and therapy, 2016 - Taylor & Francis
Triple-negative breast cancer (TNBC) represents a very heterogeneous group of breast
diseases. Currently, the backbone of therapy for TNBC is mainly chemotherapy as there are …

[HTML][HTML] Molecular targets and promising therapeutics of triple-negative breast cancer

WJ Ryu, JH Sohn - Pharmaceuticals, 2021 - mdpi.com
Triple-negative breast cancer (TNBC) is one of the most heterogeneous diseases in solid
tumors and has limited therapeutic options. Due to the lack of appropriate targetable …

[HTML][HTML] Current landscape of personalized clinical treatments for triple-negative breast cancer

J Zhang, Y Xia, X Zhou, H Yu, Y Tan, Y Du… - Frontiers in …, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is a highly malignant subtype of breast cancer (BC)
with vicious behaviors. TNBC is usually associated with relatively poor clinical outcomes …

Combined drug therapeutic strategies for the effective treatment of Triple Negative Breast Cancer

NKR Chalakur-Ramireddy, SB Pakala - Bioscience reports, 2018 - portlandpress.com
TNBC (Triple Negative Breast Cancer) is a subtype of breast cancer with an aggressive
phenotype which shows high metastatic capability and poor prognosis. Owing to its intrinsic …

[HTML][HTML] Druggable molecular targets for the treatment of triple negative breast cancer

M Nakhjavani, JE Hardingham… - Journal of breast …, 2019 - synapse.koreamed.org
Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the
subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient …

Small-molecule drug discovery in triple negative breast cancer: current situation and future directions

M Liao, J Zhang, G Wang, L Wang, J Liu… - Journal of medicinal …, 2021 - ACS Publications
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer

R Islam, KW Lam - European Journal of Medicinal Chemistry, 2020 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive type of cancer, with a high risk
of death on recurrence. To date, there is a lack of approved targeted agents for the treatment …

[HTML][HTML] Recent therapeutic trends and promising targets in triple negative breast cancer

SY Hwang, S Park, Y Kwon - Pharmacology & therapeutics, 2019 - Elsevier
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …