It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Chemotherapy is an important therapeutic option for most cancer patients; however, one
major obstacle is the occurrence of drug resistance which usually leads to failure of the …

Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer.
Poor responses to drug treatment can result in metastasis, cancer dissemination and death …

Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer
progression, metastasis and drug resistance. Although there are controversies surrounding …

Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …

Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …

Cancer cells undergo unlimited progression and survival owing to activation of oncogenes.
However, support of the tumor microenvironment is essential to the formation of clinically …

Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years,
however, acquired resistance has emerged as a daunting challenge to anticancer …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …