Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins
SARS-CoV-2 infection or vaccination produces neutralizing antibody responses that
contribute to better clinical outcomes. The receptor-binding domain (RBD) and the N …
contribute to better clinical outcomes. The receptor-binding domain (RBD) and the N …
[HTML][HTML] Conserved neutralizing epitopes on the N-terminal domain of variant SARS-CoV-2 spike proteins
Z Wang, F Muecksch, A Cho, C Gaebler, HH Hoffmann… - bioRxiv, 2022 - ncbi.nlm.nih.gov
SARS-CoV-2 infection or vaccination produces neutralizing antibody responses that
contribute to better clinical outcomes. The receptor binding domain (RBD) and the N …
contribute to better clinical outcomes. The receptor binding domain (RBD) and the N …
An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer
N Suryadevara, AR Shiakolas… - The Journal of …, 2022 - Am Soc Clin Investig
The protective human antibody response to severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the virion surface and …
2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the virion surface and …
[HTML][HTML] A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination
J Seow, H Khan, A Rosa, V Calvaresi, C Graham… - Cell Reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for
neutralizing antibodies elicited following both infection and vaccination. While extensive …
neutralizing antibodies elicited following both infection and vaccination. While extensive …
A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants
D Haslwanter, ME Dieterle, AZ Wec, CM O'brien… - Mbio, 2021 - Am Soc Microbiol
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain …
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain …
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
Summary The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-
binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient …
binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient …
Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine
R Kotaki, Y Adachi, S Moriyama, T Onodera… - Science …, 2022 - science.org
Multiple SARS-CoV-2 variants have mutations in the spike receptor binding domain (RBD)
with potential to evade neutralizing antibody. In particular, the Beta and Omicron variants …
with potential to evade neutralizing antibody. In particular, the Beta and Omicron variants …
Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-
CoV-2 infection is crucial for understanding immune protection and identifying targets for …
CoV-2 infection is crucial for understanding immune protection and identifying targets for …
Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA. 1
Neutralizing antibodies that recognize the SARS-CoV-2 spike glycoprotein are the principal
host defense against viral invasion. Variants of SARS-CoV-2 bear mutations that allow …
host defense against viral invasion. Variants of SARS-CoV-2 bear mutations that allow …