The excitation-contraction (EC) module involves a harmonized correspondence between the
sarcolemma and the sarcoplasmic reticulum. This is provided by membrane proteins, which …

Sarcolemmal membrane-associated proteins (SLMAPs) are components of cardiac
membranes involved in excitation-contraction (EC) coupling. Here, we assessed the role of …

Structural dilation of cardiomyocytes (CMs) imposes a decline in cardiac performance that
precipitates cardiac failure and sudden death. Since membrane proteins are implicated in …

Impaired cardiomyocyte contraction rate is detrimental to cardiac function and often lethal.
Despite advancements in the field, there is a paucity of information regarding the …

The cardiomyocyte plasma membrane, termed the sarcolemma, is fundamental for
regulating a myriad of cellular processes. For example, the structural integrity of the …

The sarcolemmal membrane associated proteins (SLMAPs) belong to the super family of tail
anchored membrane proteins which serve diverse roles in biology including cell growth …

Myocardial failure is associated with adverse remodeling, including loss of cardiomyocytes,
hypertrophy, and alterations in cell–cell contacts. Striatin-interacting phosphatase and …

For more than two decades, investigators who have been studying signal transduction in the
heart (and other tissues) have struggled to explain data implicating the existence of …

The spatial arrangement of the cell-surface membranes (sarcolemma and transverse
tubules) and internal membranes of the sarcoplasmic reticulum relative to the myofibril is …

The cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a critical role in
maintaining the intracellular calcium homeostasis during cardiac contraction and relaxation …