Mutant huntingtin impairs BDNF release from astrocytes by disrupting conversion of Rab3a-GTP into Rab3a-GDP
Brain-derived neurotrophic factor (BDNF) is essential for neuronal differentiation and
survival. We know that BDNF levels decline in the brains of patients with Huntington's …
survival. We know that BDNF levels decline in the brains of patients with Huntington's …
[HTML][HTML] Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
A Giralt, O Carretón, C Lao-Peregrin, ED Martín… - Molecular …, 2011 - Springer
Abstract Background Brain-Derived Neurotrophic Factor (BDNF) is the main candidate for
neuroprotective therapy for Huntington's disease (HD), but its conditional administration is …
neuroprotective therapy for Huntington's disease (HD), but its conditional administration is …
Brain‐derived neurotrophic factor over‐expression in the forebrain ameliorates Huntington's disease phenotypes in mice
Abstract Huntington's disease (HD), a dominantly inherited neurodegenerative disorder
characterized by relatively selective degeneration of striatal neurons, is caused by an …
characterized by relatively selective degeneration of striatal neurons, is caused by an …
[HTML][HTML] Decreased BDNF release in cortical neurons of a knock-in mouse model of Huntington's disease
Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by
an increase in CAG repeats in the Huntingtin gene (HTT). The striatum is one of the most …
an increase in CAG repeats in the Huntingtin gene (HTT). The striatum is one of the most …
[HTML][HTML] Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and
synaptic plasticity. It is synthesized as a precursor (pro-BDNF), sorted into the secretory …
synaptic plasticity. It is synthesized as a precursor (pro-BDNF), sorted into the secretory …
Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism
D del Toro, JM Canals, S Ginés, M Kojima… - Journal of …, 2006 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) polymorphism is associated with the
pathophysiology of several neurodegenerative disorders, including Huntington's disease. In …
pathophysiology of several neurodegenerative disorders, including Huntington's disease. In …
Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF
L Wang, F Lin, J Wang, J Wu, R Han, L Zhu, M DiFiglia… - Brain research, 2012 - Elsevier
Huntington's disease (HD) is an inheritable neurological disorder caused by an abnormal
expansion of the polyglutamine tract in the N-terminus of the protein huntingtin (htt). Mutant …
expansion of the polyglutamine tract in the N-terminus of the protein huntingtin (htt). Mutant …
[HTML][HTML] Cortical axonal secretion of bdnf in the striatum is disrupted in the mutant-huntingtin knock-in mouse model of Huntington's disease
H Park - Experimental neurobiology, 2018 - ncbi.nlm.nih.gov
Deficient BDNF signaling is known to be involved in neurodegenerative diseases such as
Huntington's disease (HD). Mutant huntingtin (mhtt)-mediated disruption of either BDNF …
Huntington's disease (HD). Mutant huntingtin (mhtt)-mediated disruption of either BDNF …
[HTML][HTML] Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
LR Gauthier, BC Charrin, M Borrell-Pagès… - Cell, 2004 - cell.com
Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for
the neuronal toxicity associated with Huntington's disease (HD). Although wild-type …
the neuronal toxicity associated with Huntington's disease (HD). Although wild-type …
BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease
A Giralt, HC Friedman, B Caneda-Ferron, N Urban… - Gene therapy, 2010 - nature.com
Brain-derived neurotrophic factor (BDNF) is the main candidate for neuroprotective
therapeutic strategies for Huntington's disease. However, the administration system and the …
therapeutic strategies for Huntington's disease. However, the administration system and the …