Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

The pathogenesis of many neurodegenerative disorders arises in association with the
misfolding and accumulation of a wide variety of proteins. Much emphasis has been placed …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …

Alpha‐synuclein (α‐syn) is a small soluble protein expressed primarily at presynaptic
terminals in the central nervous system. Interest in α‐syn has increased dramatically after …

The discovery that alpha-synuclein (α-syn) is the primary component of the
neuropathological hallmarks of Parkinson's disease (PD) and the identification of α-syn …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

• Introduction• Importance of inflammation processes in PD pathology• Stimulation of
microglia by αSyn• αSyn‐triggered stimulation of the innate immune system• Other proteins …

Parkinson's disease (PD) is one of the synucleinopathies spectrum of disorders typified by
the presence of intraneuronal protein inclusions. It is primarily composed of misfolded and …