Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

Of all the proposed causes of ageing, DNA damage remains a leading, though still debated
theory. Unlike most other types of age-related cellular damage, which can hypothetically be …

Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …

Aging is a complex, challenging phenomenon that requires multiple, interdisciplinary
approaches to unravel its puzzles. To assist basic research on aging, we developed the …

Abstract The Human Ageing Genomic Resources (HAGR) is a collection of online resources
for studying the biology of human ageing. HAGR features two main databases: GenAge and …