cAMP is a universal second messenger of many G-protein-coupled receptors and regulates
a wide variety of cellular events. cAMP exerts its effects via cAMP-dependent protein kinase …

Second messenger cAMP regulates many cellular functions through its effectors, such as
cAMP-dependent protein kinase (PKA) and Epac (exchange proteins directly activated by …

cAMP‐mediated signaling pathways regulate a multitude of important biological processes
under both physiological and pathological conditions, including diabetes, heart failure and …

The second messenger cAMP is a key mediator of signal transduction following activation of
G-protein coupled receptors. Investigations on Gs-coupled receptors would benefit from a …

The recent discovery of Epac, a novel cAMP receptor protein, opens up a new dimension in
studying cAMP-mediated cell signaling. It is conceivable that many of the cAMP functions …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

cAMP is an important second messenger with a plethora of cellular effects and biological
roles. To monitor and visualize cAMP in intact living cells, electrophysiological and …

cAMP, the classical second messenger, regulates many diverse cellular functions. The
primary effector of cAMP signals, protein kinase A, differentially phosphorylates hundreds of …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Abstract cAMP is a ubiquitous second messenger responsible for the cellular effects of
multiple hormones and neurotransmitters via activation of its main effector, protein kinase A …