The germinal centre B cell response to SARS-CoV-2
BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …
cells and memory B cells capable of mediating long-term protective immunity …
[PDF][PDF] SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation
The deployment of effective vaccines against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID …
coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID …
[HTML][HTML] Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Vaccine-mediated immunity often relies on the generation of protective antibodies and
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
[PDF][PDF] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
[HTML][HTML] SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
JS Turner, JA O'Halloran, E Kalaidina, W Kim… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 mRNA-based vaccines are about 95% effective in preventing COVID-
19 1, 2, 3, 4, 5. The dynamics of antibody-secreting plasmablasts and germinal centre B …
19 1, 2, 3, 4, 5. The dynamics of antibody-secreting plasmablasts and germinal centre B …
[HTML][HTML] Cutting edge: distinct B cell repertoires characterize patients with mild and severe COVID-19
Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2–
specific plasma cells and memory B cells postinfection or postvaccination. Previous work …
specific plasma cells and memory B cells postinfection or postvaccination. Previous work …
[HTML][HTML] The robustness of cellular immunity determines the fate of SARS-CoV-2 infection
E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …
global pandemic, it is time to analyze the evolution of the immune protection that infection …
[PDF][PDF] Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help
J Pušnik, E Richter, B Schulte, R Dolscheid-Pommerich… - Cell Reports, 2021 - cell.com
Memory B cells seem to be more durable than antibodies and thus crucial for the long-term
immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2
Y Zurbuchen, J Michler, P Taeschler, S Adamo… - Nature …, 2023 - nature.com
The B cell response to different pathogens uses tailored effector mechanisms and results in
functionally specialized memory B (Bm) cell subsets, including CD21+ resting, CD21 …
functionally specialized memory B (Bm) cell subsets, including CD21+ resting, CD21 …
Durable SARS-CoV-2 B cell immunity after mild or severe disease
Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2–
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …