Importance Primary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve …

The American College of Cardiology/American Heart Association pooled cohort equations
tool (ASCVD-PCE) is currently recommended to assess 10-year risk for atherosclerotic …

Background: Understanding the predictive utility of previously derived polygenic risk scores
(PRSs) for long-term risk of coronary heart disease (CHD) and its additive value beyond …

The predictive ability of coronary heart disease (CHD) and ischemic stroke (IS) polygenic
risk scores (PRS) have been evaluated individually, but whether they predict the combined …

Clinical implementation of new prediction models requires evaluation of their utility in a
broad range of intended use populations. Here we develop and validate ancestry-specific …

Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …

A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …

Polygenic risk scores (PRSs) are central to the development of precision medicine.
However, decades of Euro-centric genomics research have paved the way for disparities in …

Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from
mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic …

Background Algorithms including both traditional risk factors and polygenic risk scores
(PRS) can significantly improve prediction of atherosclerotic cardiovascular disease …