Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

SS Dominy, C Lynch, F Ermini, M Benedyk… - Science …, 2019 - science.org
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in
the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …

Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies

MI Ryder - Journal of periodontology, 2020 - Wiley Online Library
Epidemiological studies have identified an association between periodontitis and Alzheimer
disease (AD); however, the nature of this association has been unclear. Recent work …

Alzheimer's disease-like neurodegeneration in Porphyromonas gingivalis infected neurons with persistent expression of active gingipains

U Haditsch, T Roth, L Rodriguez… - Journal of …, 2020 - content.iospress.com
Background: Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors
have been identified as pathogenic effectors in Alzheimer's disease (AD). In a recent study …

Porphyromonas gingivalis

L Reyes - Trends in Microbiology, 2021 - cell.com
Porphyromonas gingivalis is a Gram-negative, rod-shaped, obligate anaerobe that obtains
its metabolic energy from protein breakdown products, heme, and vitamin K for its growth. It …

Porphyromonas gingivalis is a strong risk factor for Alzheimer's disease

S Kanagasingam, SS Chukkapalli… - Journal of …, 2020 - content.iospress.com
Porphyromonas gingivalis (P. gingivalis) is one of the several important bacterial pathogens
associated with the sporadic Alzheimer's disease (AD). Different serotypes are either …

Alzheimer disease and the periodontal patient: New insights, connections, and therapies

MI Ryder, P Xenoudi - Periodontology 2000, 2021 - Wiley Online Library
Loss of cognitive function in the aging population, particular those with Alzheimer disease,
presents unique challenges to health practitioners. For the dental practitioner these include …

Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease

SK Singhrao, A Harding, S Poole… - Mediators of …, 2015 - Wiley Online Library
Periodontal disease (PD) and Alzheimer's disease (AD) are inflammatory conditions
affecting the global adult population. In the pathogenesis of PD, subgingival complex …

Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer's disease

SK Singhrao, I Olsen - Journal of oral microbiology, 2019 - Taylor & Francis
Chronic periodontitis of 10 years' duration is reported to become a twofold risk factor for the
development of Alzheimer's disease (AD). Periodontitis is modifiable, and this fits with the …

Porphyromonas gingivalis as a risk factor to Alzheimer's disease: A systematic review

A Elwishahy, K Antia, S Bhusari… - Journal of …, 2021 - content.iospress.com
Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease that
accounts for more than 50% of all dementia cases worldwide. There is wide consensus on …

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease …

Y Liu, Z Wu, Y Nakanishi, J Ni, Y Hayashi… - Scientific reports, 2017 - nature.com
Despite a clear correlation between periodontitis and cognitive decline in Alzheimer's
disease, the precise mechanism underlying the relationship remains unclear. The …