Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

SK Pandey, U Anand, WA Siddiqui… - Advances in …, 2023 - Wiley Online Library
Malaria continued to be a deadly situation for the people of tropical and subtropical
countries. Although there has been a marked reduction in new cases as well as mortality …

The global portfolio of new antimalarial medicines under development

P Olliaro, TNC Wells - Clinical Pharmacology & Therapeutics, 2009 - Wiley Online Library
With the elimination of malaria now considered a realistic goal, it would be useful for
scientists and policy makers to have an inventory of the arsenal of antimalarials, current and …

Antimalarial drug discovery–the path towards eradication

JN Burrows, E Burlot, B Campo, S Cherbuin… - Parasitology, 2014 - cambridge.org
Malaria is a disease that still affects a significant proportion of the global human population.
Whilst advances have been made in lowering the numbers of cases and deaths, it is clear …

Malaria medicines: a glass half full?

TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

[PDF][PDF] Antimalarial drug development: past to present scenario

M Dhanawat, N Das, RC Nagarwal… - Mini Reviews in …, 2009 - researchgate.net
Malaria is a global health problem that needs attention of drug discovery scientists to
investigate novel compounds with high drug efficacy, safety and low cost to counter the …

Drug discovery for malaria: a very challenging and timely endeavor

MH Gelb - Current opinion in chemical biology, 2007 - Elsevier
The prevalence of resistance to known antimalarial drugs has resulted in the expansion of
antimalarial drug discovery efforts. Academic and nonprofit institutions are partnering with …

Expanding the antimalarial drug arsenal—Now, but how?

BT Grimberg, RK Mehlotra - Pharmaceuticals, 2011 - mdpi.com
The number of available and effective antimalarial drugs is quickly dwindling. This is mainly
because a number of drug resistance-associated mutations in malaria parasite genes, such …

[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives

S Kumar, TR Bhardwaj, DN Prasad… - Biomedicine & …, 2018 - Elsevier
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development

M Schlitzer - ChemMedChem: Chemistry Enabling Drug …, 2007 - Wiley Online Library
Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

New dimensions in the field of antimalarial research against malaria resurgence

AK Narula, CS Azad, LM Nainwal - European Journal of Medicinal …, 2019 - Elsevier
Malaria is a life threatening disease caused by microscopic parasites called Plasmodium
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …