NSAIDs/nitazoxanide/azithromycin repurposed for COVID-19: potential mitigation of the cytokine storm interleukin-6 amplifier via immunomodulatory effects

MT Kelleni - Expert Review of Anti-infective Therapy, 2022 - Taylor & Francis
Introduction Mediators of immunity and inflammation are playing a crucial role in COVID-19
pathogenesis and complications as demonstrated by several genetic and clinical studies …

[PDF][PDF] Potential dual therapeutic approach against SARS-CoV-2/COVID-19 with Nitazoxanide and Hydroxychloroquine

M Srivatsan Padmanabhan - 2020 - researchgate.net
Coronaviruses are ubiquitous in nature and infects diverse species with frequent cross-
species transmission. There have been multiple events of animal to human transmission …

A meta analysis on the utility of Anakinra in severe COVID-19 disease

AARM Hussein, R Sayad, A Abdelshafi, IA Hammam… - Cytokine, 2023 - Elsevier
Background and objective The most important presentation of COVID-19 is hyper
inflammatory condition and cytokine storm that occurs due to excessive increase of the …

COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon

HC Hasselbalch, V Skov, L Kjær, C Ellervik… - Cytokine & growth factor …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits an interferon (IFN)
deficiency state, which aggravates the type I interferon deficiency and slow IFN responses …

[HTML][HTML] Immunomodulatory effects of azithromycin revisited: potential applications to COVID-19

VJ Venditto, D Haydar, A Abdel-Latif… - Frontiers in …, 2021 - frontiersin.org
The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to
identify effective therapeutics. Stages of the disease course have been defined by viral …

[HTML][HTML] A review of treatment of coronavirus disease 2019 (COVID-19): Therapeutic repurposing and unmet clinical needs

PL Chen, NY Lee, CT Cia, WC Ko… - Frontiers in …, 2020 - frontiersin.org
For the initial phase of pandemic of coronavirus disease 2019 (COVID-19), repurposing
drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

[HTML][HTML] Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs …

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …

Nitazoxanide/azithromycin combination for COVID-19: A suggested new protocol for early management

MT Kelleni - Pharmacological research, 2020 - Elsevier
Azithromycin has been shown to have a clinical efficacy against severe acute respiratory
syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental …

[HTML][HTML] Immunomodulatory drugs in the management of SARS-CoV-2

DR Burrage, S Koushesh, N Sofat - Frontiers in immunology, 2020 - frontiersin.org
With the onset of the global pandemic in 2020 of Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2), there has been increasing research activity around certain …

[HTML][HTML] NSAIDs and Kelleni's protocol as potential early COVID-19 treatment game changer: could it be the final countdown?

MT Kelleni - Inflammopharmacology, 2022 - Springer
We have previously published several papers illustrating numerous immunomodulatory and
anti-inflammatory potential benefits when we repurposed safe, generic non-steroidal anti …