Ovarian cancer is the deadliest gynaecologic malignancy, and the five-year survival rate of
patients is less than 35% worldwide. Cancer stem cells (CSCs) are a population of cells with …

Background: Drug resistance is well known as a major obstacle for cancer recurrence and
treatment failure, leading to poor survival in pancreatic cancer, which is a highly aggressive …

Hepatocellular carcinoma (HCC) is the most common cancer in the world especially in East
Asia and Africa. Advanced stage, metastasis and frequent relapse are responsible for the …

Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular
biology has been extensively studied resulting in identification of a complex nature of …

Emerging evidence suggests that the members of the tripartite motif (TRIM) family play a
crucial role in cancer development and progression. The purpose of the study was to …

The aim of our work is to clarify the clinical implication and functional role of tripartite motif 21
(TRIM21) in hepatocellular carcinoma (HCC). We validated that TRIM21 was downregulated …

TRIM protein family is an evolutionarily conserved gene family implicated in a number of
critical processes including inflammation, immunity, antiviral and cancer. In an effort to …

Hepatocellular carcinoma (HCC) is the one of the most common malignancies worldwide
and its prognosis is extremely poor. Tripartite motif (TRIM) proteins play crucial roles in …

Background Colorectal cancer (CRC) is one of the most lethal malignancies. Tripartite Motif
Containing 14 (TRIM14) is a member of TRIM family proteins, which are involved in the …

Abstract Tripartite motif‑containing 27 (TRIM27) belongs to the tripartite motif (TRIM) protein
family and is involved in various malignant tumor processes. However, the function and …