Derangements in adrenergic–adipokine signalling establish a neurohormonal basis for obesity‐related heart failure with a preserved ejection fraction

M Packer - European journal of heart failure, 2018 - Wiley Online Library
Among patients with heart failure and a preserved ejection (HFpEF), obesity is associated
with a distinct phenotype that is characterized by adiposity‐driven plasma volume expansion …

Obesity-related heart failure with a preserved ejection fraction: the mechanistic rationale for combining inhibitors of aldosterone, neprilysin, and sodium-glucose …

M Packer, DW Kitzman - JACC: Heart Failure, 2018 - jacc.org
Obesity-related heart failure with a preserved ejection fraction (HFpEF) is an important
phenotype prevalent in the community, especially in people with metabolic disorders (eg …

Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity

M Packer - Circulation, 2018 - Am Heart Assoc
Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

BA Borlaug, MD Jensen, DW Kitzman… - Cardiovascular …, 2022 - academic.oup.com
Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Cardio‐adipose tissue cross‐talk: relationship between adiponectin, plasma pro brain natriuretic peptide and incident heart failure

S Lindberg, JS Jensen, M Bjerre… - European journal of …, 2014 - Wiley Online Library
Aims There is increasing evidence of cross‐talk between the heart, body metabolism, and
adipose tissue, but the precise mechanisms are poorly understood. Natriuretic peptides …

Targeting obesity and diabetes to treat heart failure with preserved ejection fraction

R Altara, M Giordano, ES Nordén, A Cataliotti… - Frontiers in …, 2017 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is a major unmet medical need that is
characterized by the presence of multiple cardiovascular and non-cardiovascular …

Heart failure with preserved ejection fraction induces beiging in adipose tissue

M Valero-Muñoz, S Li, RM Wilson… - Circulation: Heart …, 2016 - Am Heart Assoc
Background—Despite the increasing prevalence of heart failure with preserved ejection
fraction (HFpEF) in humans, there are no evidence-based therapies for HFpEF. Clinical …

[HTML][HTML] Emphasis on abdominal obesity as a modifier of eplerenone effect in heart failure: hypothesis-generating signals from EMPHASIS-HF

A Ahmed, MR Blackman, M White… - European journal of heart …, 2017 - ncbi.nlm.nih.gov
Heart failure (HF) has interesting relationships with some of its risk factors. For example,
both high blood pressure and smoking are risk factors for incident HF, but for patients with …

Drugs that ameliorate epicardial adipose tissue inflammation may have discordant effects in heart failure with a preserved ejection fraction as compared with a …

M Packer - Journal of Cardiac Failure, 2019 - Elsevier
Heart failure with a preserved ejection fraction (HFpEF) and heart failure with a reduced
ejection fraction (HFrEF) have distinctive pathophysiologies, and thus, therapeutic …

Heart failure with preserved ejection fraction and adipose tissue: a story of two tales

A Oh, R Okazaki, F Sam… - Frontiers in Cardiovascular …, 2019 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …