Growth factors in the pathogenesis of retinal neurodegeneration in diabetes mellitus

BS Iwona - Current Neuropharmacology, 2016 - ingentaconnect.com
Neurodegeneration is an initial process in the development of diabetic retinopathy (DR).
High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system …

[HTML][HTML] Neurodegeneration: an early event of diabetic retinopathy

M Villarroel, A Ciudin, C Hernández… - World journal of …, 2010 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) has been classically considered to be a microcirculatory disease
of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the …

[HTML][HTML] Alteration of growth factors and neuronal death in diabetic retinopathy: what we have learned so far

W Whitmire, MMH Al-Gayyar, M Abdelsaid… - Molecular …, 2011 - ncbi.nlm.nih.gov
Purpose Diabetic retinopathy (DR) is a leading cause of blindness in American adults. Over
the years, DR has been perceived as a vascular disease characterized by vascular …

Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy

MS Ola, MI Nawaz, MM Siddiquei, S Al-Amro… - Journal of Diabetes and …, 2012 - Elsevier
One of the major complications in patients with diabetes is diabetic retinopathy (DR), a
leading cause of blindness worldwide. It takes several years before any clinical signs of …

Neuroprotection in diabetic retinopathy

C Hernandez, R Simó - Current diabetes reports, 2012 - Springer
Diabetic retinopathy (DR) has been considered to be a microcirculatory disease of the
retina. However, there is emerging evidence to suggest that retinal neurodegeneration is an …

Neurodegeneration as a primary change and role of neuroprotection in diabetic retinopathy

V Jindal - Molecular neurobiology, 2015 - Springer
Diabetic retinopathy (DR) was earlier recognized as a vascular disease, but nowadays, it is
considered as a neurovascular disorder. Neuronal death is the primary change which leads …

Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy

G Zerbini, S Maestroni, L Leocani, A Mosca… - Frontiers in …, 2022 - frontiersin.org
Specific and effective preventive treatment for diabetic retinopathy (DR) is presently
unavailable, mostly because the early stages of the complication have been, until recently …

Diabetic retinopathy and BDNF: a review on its molecular basis and clinical applications

M Afarid, E Namvar… - Journal of ophthalmology, 2020 - Wiley Online Library
Impairment of neuroprotection and vasculopathy are the main reasons for the progression of
diabetic retinopathy. In this review, we decided to illustrate the molecular and clinical …

Relationships between neurodegeneration and vascular damage in diabetic retinopathy

MG Rossino, M Dal Monte, G Casini - Frontiers in neuroscience, 2019 - frontiersin.org
Diabetic retinopathy (DR) is a common complication of diabetes and constitutes a major
cause of vision impairment and blindness in the world. DR has long been described …

Neurodegeneration in diabetic retina and its potential drug targets

M Shamsul Ola, AS Alhomida - Current neuropharmacology, 2014 - ingentaconnect.com
Diabetic retinopathy (DR) is one of the major complications of diabetes causing vision loss
and blindness worldwide. DR is widely recognized as a neurodegenerative disease as …