Ischemic stroke involves a series of complex pathological mechanisms, of which
neuroinflammation is currently the most widely recognized. C–C motif chemokine receptor 5 …

Background: Stroke is the second leading cause of death and a major cause of disability of
adults worldwide. Inflammatory processes are known to contribute to the pathophysiology of …

Background and purpose: The chemokine receptor CCR5 is well known for its function in
immune cells; however, it is also expressed in the brain, where its specific role remains to be …

Abstract Chemokine (CC motif) receptor 5 (CCR5) is expressed not only in the immune cells
but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high …

CC motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein
family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate …

Stroke is the world's second major cause of adult death and disability, resulting in the
destruction of brain tissue and long-term neurological impairment; induction of neuronal …

Background and Purpose—The chemokine, monocyte chemoattractant protein-1 (CCL2), is
a major factor driving leukocyte infiltration into the brain parenchyma in a variety of …

We examined the role of CCRL2 in ischemic brain injury using both in vitro and in vivo
mouse stroke models. The expression of CCRL2 was enhanced at both the RNA and protein …

Abstract Background Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/CX3C chemokine
receptor 1 (CX3CR1) signaling is important in modulating the communication between …

Stroke is the second cause of mortality worldwide and occurs following the interruption of
cerebral blood circulation by cerebral vessel burst or subsequent to a local thrombus …