For transdermal absorption studies, a porcine skin model that maintains the characteristics
of the skin as close to physiological conditions as possible should be established because …

The optimal skin type for in vitro permeability studies depends on the purpose of the specific
transdermal study. In a number of cases, it may be advantageous to use animal skin as an …

The assessment of the percutaneous absorption of drugs and xenobiotics has been limited
by the relatively simple nature of previous experimental models. The study of the function of …

Porcine skin has frequently been used as a model in in vitro permeation studies being
considered as an excellent alternative for human skin due to biochemical similarities. The …

Using udders from slaughtered cows as a new in vitro model of percutaneous drug
absorption, the tissue viability and the percutaneous absorption of dexamethasone, benzoyl …

The isolated perfused porcine skin flap (IPPSF) is a new perfused skin model which allows
in vitro cutaneous pharmacology and toxicology studies to be conducted in a viable skin …

Rat and pig animal skin has been the most common replacement material for human skin for
use in in vitro permeability experiments. Unfortunately, the permeability barrier of skin from …

The pig has been a well-recognized experimental animal in biomedical research for many
centuries. Physiological and anatomical similarities between man and pig made this animal …

A protocol for percutaneous absorption studies has been validated, based on the use of
reconstructed human epidermis (RHE) and aqueous solutions of test substances. However …

Abstract Aim and Methods: Drug development in dermatotherapy and also development of
transdermal therapeutic systems (TTS) demand high-predictive in vitro models to estimate …