Background Whether preventive inhaled antibiotics may reduce the incidence of ventilator-
associated pneumonia is unclear. Methods In this investigator-initiated, multicenter, double …

Background Treatment of ventilated pneumonia is often unsuccessful, even when patients
are treated according to established guidelines. Therefore, we aimed to investigate the …

Purpose To conduct a multicenter, randomized, placebo-controlled, double-blind, phase II
study of BAY41-6551 (NCT01004445), an investigational drug–device combination of …

Background Clinical failures in ventilator-associated pneumonia (VAP) caused by gram-
negative bacteria are common and associated with substantial morbidity, mortality, and …

Lung tissue deposition and antibacterial efficiency of nebulized and intravenous amikacin
(AMK) were compared in anesthetized and ventilated piglets suffering from a …

The ability to deliver high concentrations of antimicrobial agents directly to the site of
pneumonia is attractive, especially with the availability of high-efficiency nebulizers. A major …

Introduction The administration of prophylactic antibiotics via the respiratory tract is one of
several strategies for the prevention of intensive care unit (ICU)-acquired pneumonia. We …

Background: This clinical trial evaluated the pharmacokinetics and safety/tolerability of
amikacin/fosfomycin solution using a vibrating plate nebulizer, in mechanically ventilated …

Nosocomial pneumonia is a leading cause of death from hospital-acquired infections, with
an associated crude mortality rate of approximately 30 percent. 1 Ventilator-associated …

Rationale: In experimental pneumonia, nebulization of antibiotics provides high lung tissue
concentrations and rapid bacterial killing. Objectives: To assess the efficacy and safety of …