COVID-19 is a disease with unique characteristics that include lung thrombosis, frequent
diarrhoea, abnormal activation of the inflammatory response and rapid deterioration of lung …

The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …

Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …

Antiviral therapeutics are a front-line defense against virally induced diseases. Because
viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …

Severe COVID‐19 is characterized by lung abnormalities, including the presence of
syncytial pneumocytes. Syncytia form when SARS‐CoV‐2 spike protein expressed on the …

Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …

Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …