[HTML][HTML] Fibrosis: from mechanisms to medicines

NC Henderson, F Rieder, TA Wynn - Nature, 2020 - nature.com
Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Therapy for fibrotic diseases: nearing the starting line

SL Friedman, D Sheppard, JS Duffield… - Science translational …, 2013 - science.org
Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic …

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

TA Wynn, TR Ramalingam - Nature medicine, 2012 - nature.com
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies

I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Drugs and targets in fibrosis

X Li, L Zhu, B Wang, M Yuan, R Zhu - Frontiers in pharmacology, 2017 - frontiersin.org
Fibrosis contributes to the development of many diseases and many target molecules are
involved in fibrosis. Currently, the majority of fibrosis treatment strategies are limited to …

Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis

M Zeisberg, R Kalluri - American Journal of Physiology-Cell …, 2013 - journals.physiology.org
Fibrosis is a pathological scarring process that leads to destruction of organ architecture and
impairment of organ function. Chronic loss of organ function in most organs, including bone …

Deciphering the cellular mechanisms underlying fibrosis-associated diseases and therapeutic avenues

H Miao, XQ Wu, DD Zhang, YN Wang, Y Guo… - Pharmacological …, 2021 - Elsevier
Fibrosis is the excessive deposition of extracellular matrix components, which results in
disruption of tissue architecture and loss of organ function. Fibrosis leads to high morbidity …

Shared and distinct mechanisms of fibrosis

JHW Distler, AH Györfi, M Ramanujam… - Nature Reviews …, 2019 - nature.com
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

CB Nanthakumar, RJD Hatley, S Lemma… - Nature reviews Drug …, 2015 - nature.com
Fibrosis, which leads to progressive loss of tissue function and eventual organ failure, has
been estimated to contribute to~ 45% of deaths in the developed world, and so new …

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …