Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep
serum proteome survey recently revealed close associations between serum protein …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

Background The human plasma proteome is important for many biological processes and
targets for diagnostics and therapy. It is therefore of great interest to understand the interplay …

Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

The human proteome is a crucial intermediate between complex diseases and their genetic
and environmental components, and an important source of drug development targets and …

Integrating human genomics and proteomics can help elucidate disease mechanisms,
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …

Human physiology is complex, with integrated networks of tissues and organs that
coordinate complex functions. Within this network of networks, the blood is a uniquely …

Background Precision medicine approaches aim to tackle diseases on an individual level
through molecular profiling. Despite the growing knowledge about diseases and the …

The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …