Staphylococcal superantigens in colonization and disease

SX Xu, JK McCormick - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be
produced by only a few bacterial pathogens, including Staphylococcus aureus. More than …

Manipulation of innate and adaptive immunity by staphylococcal superantigens

SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Staphylococcal superantigens interact with multiple host receptors to cause serious diseases

CS Stach, A Herrera, PM Schlievert - Immunologic research, 2014 - Springer
Staphylococcus aureus strains that cause human diseases produce a large family of
pyrogenic toxin superantigens (SAgs). These include toxic shock syndrome toxin-1 (TSST …

Allergy—A New Role for T Cell Superantigens of Staphylococcus aureus?

G Abdurrahman, F Schmiedeke, C Bachert, BM Bröker… - Toxins, 2020 - mdpi.com
Staphylococcus aureus superantigens (SAgs) are among the most potent T cell mitogens
known. They stimulate large fractions of T cells by cross-linking their T cell receptor with …

Bacterial superantigens

T Proft, JD Fraser - Clinical & Experimental Immunology, 2003 - academic.oup.com
Superantigens (SAgs) are the most powerful T cell mitogens ever discovered.
Concentrations of less than 0· 1 pg/ml of a bacterial superantigen are sufficient to stimulate …

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production

SW Tuffs, MI Goncheva, SX Xu… - Proceedings of the …, 2022 - National Acad Sciences
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Toxic shock syndrome and bacterial superantigens: an update

JK McCormick, JM Yarwood… - Annual Reviews in …, 2001 - annualreviews.org
▪ Abstract Toxic shock syndrome (TSS) is an acute onset illness characterized by fever, rash
formation, and hypotension that can lead to multiple organ failure and lethal shock, as well …

Superantigens Subvert the Neutrophil Response To Promote Abscess Formation and Enhance Staphylococcus aureus Survival In Vivo

SX Xu, KJ Gilmore, PA Szabo, JJ Zeppa… - Infection and …, 2014 - Am Soc Microbiol
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating
toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can …

[HTML][HTML] Streptococcal superantigens: biological properties and potential role in disease

T Proft, JD Fraser - 2016 - europepmc.org
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …

Staphylococcal superantigen super-domains in immune evasion

R Langley, D Patel, N Jackson, F Clow… - Critical Reviews™ in …, 2010 - dl.begellhouse.com
Staphylococcus aureus is a robust pathogen that is capable of growing in virtually any part
of the human body, and can also survive and grow in many other species. S. aureus remains …