Metallo-β-lactamases (MBLs) are class B β-lactamases from the metallo-hydrolase-like MBL-
fold superfamily which act on a broad range of β-lactam antibiotics. A previous study on …

BLEG-1 from Bacillus lehensis G1 is an evolutionary divergent B3 metallo-β-lactamase
(MBL) that exhibited both β-lactamase and glyoxalase II (GLXII) activities. Sequence …

The effectiveness of β-lactam antibiotics as chemotherapeutic agents to treat bacterial
infections is gradually threatened with the emergence of antibiotic resistance mechanism …

Previously, a hypothetical protein (HP) termed Bleg1_2437 (currently named Bleg1_2478)
from Bacillus lehensis G1 was discovered to be an evolutionary divergent B3 subclass …

ABSTRACT β-Lactamase production increasingly threatens the effectiveness of β-lactams,
which remain a mainstay of antimicrobial chemotherapy. New activities emerge through both …

Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics, including penicillins,
cephalosporins, and carbapenems; however, no effective inhibitors are currently clinically …

Abstract Metallo-β-lactamases (MBLs) are a group of enzymes that can inactivate most
commonly used β-lactam-based antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 …

Resistance to β-lactams is one of the most serious problems associated with Gram-negative
infections. β-Lactamases are able to hydrolyze β-lactams such as cephalosporins and/or …

The structural diversity in metallo-β-lactamases (MBLs), especially in the vicinity of the active
site, has been a major hurdle in the development of clinically effective inhibitors …

The metallo‐β‐lactamase (MBL) GOB‐1 was expressed via a T7 expression system in
Escherichia coli BL21 (DE3). The MBL was purified to homogeneity and shown to exhibit a …