Defining the environmental context in which genes enhance disease susceptibility can
provide insight into the pathogenesis of complex disorders. We report that the intra-uterine …

Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …

Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …

While genetic factors account for a significant proportion of liability to schizophrenia, a body
of evidence attests to a significant environmental contribution. Understanding the …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

Since a proposal in 1986 that schizophrenia involved early neurodevelopmental deviations
beginning in intrauterine life that showed varying expressivity as relevant neural systems …

Background Schizophrenia is caused by a combination of genetic and environmental
factors, as first evidenced by twin studies. Extensive efforts have been made to identify the …

We provide a brief review of findings supporting a role for prenatal infection in the etiology of
schizophrenia. Our group and others have conducted birth cohort studies to address …

Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …