La progression normale du développement embryonnaire précoce dépend de plusieurs
processus cellulaires tels que les modifications épigénétiques, la réorganisation de la …

Negative elongation factor (NELF), a four-subunit protein complex in metazoan, plays an
important role in regulating promoter-proximal pausing of RNA polymerase II (RNAPII) …

A hallmark of genes that are subject to developmental regulation of transcriptional
elongation is association of the negative elongation factor NELF with the paused RNA …

Negative Elongation Factor (NELF) is a transcription factor discovered based on its
biochemical activity to suppress transcription elongation, and has since been implicated in …

The transcription rate of immediate early genes (IEGs) is controlled directly by transcription
elongation factors at the transcription elongation step. Negative elongation factor (NELF) …

Zygotic genome activation (ZGA) is a major event during cleavage development. In vitro
manipulation of mammalian embryos (including embryo culture) can result in developmental …

For Drosophila embryos, gastrulation happens within a 30 minute window, spanning the
completion of cellularization and the beginning of germ band extension. During this short …

For many years it was believed that promoter-proximal RNA-polymerase II (Pol II) pausing
manages the transcription of genes in Drosophila development by controlling …

Nanog homeobox (NANOG) is the gateway to the pluripotent ground state in mouse
embryonic stem cells and early embryos. However, understanding of the molecular …

Transcription regulation in metazoans often involves promoter-proximal pausing of RNA
polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF). Here we …