Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

D Ellinghaus, L Jostins, SL Spain, A Cortes… - Nature …, 2016 - nature.com
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate …

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

SG Ji, BD Juran, S Mucha, T Folseraas, L Jostins… - Nature …, 2017 - nature.com
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

JZ Liu, JR Hov, T Folseraas, E Ellinghaus… - Nature …, 2013 - nature.com
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

Fine-mapping inflammatory bowel disease loci to single-variant resolution

H Huang, M Fang, L Jostins, M Umićević Mirkov… - Nature, 2017 - nature.com
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect
millions of people worldwide. Genome-wide association studies have identified 200 …

Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

MR Lincoln, N Connally, PP Axisa, C Gasperi… - Nature Genetics, 2024 - nature.com
Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …

Common variants at five new loci associated with early-onset inflammatory bowel disease

M Imielinski, RN Baldassano, A Griffiths, RK Russell… - Nature …, 2009 - nature.com
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

E Melum, A Franke, C Schramm, TJ Weismüller… - Nature …, 2011 - nature.com
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4–7.5% of
individuals with inflammatory bowel disease. We performed a genome-wide association …

Recent insights into the genetics of inflammatory bowel disease

JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

DPB McGovern, A Gardet, L Törkvist, P Goyette… - Nature …, 2010 - nature.com
Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract
with a complex genetic and environmental etiology. In an effort to identify genetic variation …

[HTML][HTML] Genetics of inflammatory bowel disease from multifactorial to monogenic forms

AM Bianco, M Girardelli… - World journal of …, 2015 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a group of chronic multifactorial disorders. According to
a recent study, the number of IBD association loci is increased to 201, of which 37 and 27 …